A brick frame is a load-bearing supporting structure for a building or other built object, which is composed of many individual solid blocks of baked minerals (usually a mixture of sand, clay, shale, etc. with water) stacked together and joined with mortar.

Load-bearing bricks may be perforated by a small number of holes for lightness, but if their mass is reduced by 20% or more by through-perforations then they form a cellular brick structural frame. Regular brick is less good as an insulator, but may be supplemented by interior or exterior insulation. It is more suitable than cellular brick as an exposed external facade because of its more attractive range of textures, forms, and colors.

The stacked, mortared units carry structural loads. A brick veneer attached to a different supporting frame does not establish a brick framing system; the separate cellular-brick threshold remains at least 20 percent through-perforation.