A second-hand clothing store is a retail space specializing in the sale of used, unwanted, or returned clothing, usually at a discount and often for charitable or non-profit purposes. It may purchase clothing items from the past owners for money, or it may accept donations.

The stock can include unwanted or returned clothing that has not been worn. Previous use is one route into the assortment, and both buying from owners and accepting donations are included.

Charitable operation and discounted prices are common but are not required. A second-hand baby clothing store has the additional infant-clothing specialization; this broader store can sell clothing for other ages.